| Rank | Land Area ▼ | School District / Population |
| 1. | 1,133.90 sq mi | Horry County School District / 283,280 |
| 2. | 1,098.86 sq mi | Berkeley County School District / 188,835 |
| 3. | 1,056.49 sq mi | Colleton County School District / 38,247 |
| 4. | 1,032.09 sq mi | Aiken County School District / 165,978 |
| 5. | 934.16 sq mi | Williamsburg County School District / 33,560 |
| 6. | 916.09 sq mi | Charleston County School District / 365,674 |
| 7. | 813.55 sq mi | Georgetown County School District / 60,389 |
| 8. | 799.47 sq mi | Greenville County School District / 482,484 |
| 9. | 799.07 sq mi | Chesterfield County School District / 46,333 |
| 10. | 726.56 sq mi | Kershaw County School District / 62,342 |
| 11. | 686.28 sq mi | Fairfield County School District / 23,382 |
| 12. | 655.32 sq mi | Jasper County School District / 26,042 |
| 13. | 630.04 sq mi | Newberry County School District / 37,593 |
| 14. | 626.33 sq mi | Oconee County School District / 74,656 |
| 15. | 615.07 sq mi | Sumter School District 2 / 57,252 |
| 16. | 580.66 sq mi | Chester County School District / 32,708 |
| 17. | 567.51 sq mi | Beaufort County School District / 167,504 |
| 18. | 561.15 sq mi | Darlington County School District / 68,161 |
| 19. | 549.16 sq mi | Lancaster County School District / 79,515 |
| 20. | 514.17 sq mi | Union County School District / 28,329 |
| 21. | 500.41 sq mi | Edgefield County School District / 26,573 |
| 22. | 496.41 sq mi | Pickens County School District / 119,577 |
| 23. | 482.48 sq mi | Abbeville County School District / 23,891 |
| 24. | 479.67 sq mi | Marlboro County School District / 28,294 |
| 25. | 449.21 sq mi | Richland School District 1 / 206,981 |
| 26. | 417.01 sq mi | Orangeburg School District 4 / 20,108 |
| 27. | 415.36 sq mi | Orangeburg School District 5 / 50,688 |
| 28. | 410.18 sq mi | Lee County School District / 18,708 |
| 29. | 408.09 sq mi | Allendale County School District / 10,027 |
| 30. | 381.15 sq mi | Calhoun County School District / 15,031 |
| 31. | 379.10 sq mi | Cherokee County School District / 53,716 |
| 32. | 359.13 sq mi | McCormick County School District / 10,003 |
| 33. | 349.09 sq mi | Laurens School District 55 / 36,736 |
| 34. | 340.48 sq mi | Dorchester School District 4 / 16,296 |
| 35. | 335.59 sq mi | Lexington School District 1 / 126,307 |
| 36. | 333.06 sq mi | Saluda County School District / 15,250 |
| 37. | 319.44 sq mi | Greenwood School District 50 / 58,892 |
| 38. | 309.63 sq mi | York School District 1 / 32,570 |
| 39. | 306.57 sq mi | Hampton School District 1 / 13,195 |
| 40. | 305.03 sq mi | Clarendon School District 2 / 18,553 |
| 41. | 293.76 sq mi | Florence School District 1 / 100,376 |
| 42. | 287.93 sq mi | Laurens School District 56 / 20,894 |
| 43. | 273.73 sq mi | Orangeburg School District 3 / 20,466 |
| 44. | 253.32 sq mi | Hampton School District 2 / 7,475 |
| 45. | 242.73 sq mi | Bamberg School District 1 / 8,611 |
| 46. | 232.75 sq mi | Dorchester School District 2 / 126,476 |
| 47. | 232.65 sq mi | Marion School District 7 / 6,077 |
| 48. | 191.54 sq mi | Florence School District 3 / 19,559 |
| 49. | 183.64 sq mi | York School District 3 / 112,078 |
| 50. | 183.50 sq mi | Barnwell School District 45 / 11,915 |
| 51. | 179.29 sq mi | Clarendon School District 1 / 9,313 |
| 52. | 170.06 sq mi | Marion School District 1 / 15,337 |
| 53. | 161.07 sq mi | Spartanburg School District 4 / 18,504 |
| 54. | 159.60 sq mi | Anderson School District 3 / 15,039 |
| 55. | 157.17 sq mi | Richland School District 2 / 128,949 |
| 56. | 156.32 sq mi | Anderson School District 1 / 49,874 |
| 57. | 153.04 sq mi | Anderson School District 2 / 23,295 |
| 58. | 150.96 sq mi | Florence School District 2 / 6,878 |
| 59. | 150.64 sq mi | Bamberg School District 2 / 7,038 |
| 60. | 150.18 sq mi | Dillon School District 3 / 8,077 |
| 61. | 149.44 sq mi | Spartanburg School District 6 / 61,345 |
| 62. | 147.77 sq mi | Spartanburg School District 2 / 58,913 |
| 63. | 144.42 sq mi | Dillon School District 2 / 23,452 |
| 64. | 144.03 sq mi | Anderson School District 4 / 21,928 |
| 65. | 137.82 sq mi | Spartanburg School District 1 / 29,714 |
| 66. | 137.43 sq mi | Lexington School District 3 / 12,749 |
| 67. | 133.48 sq mi | York School District 2 / 36,439 |
| 68. | 130.22 sq mi | Lexington School District 5 / 93,939 |
| 69. | 122.62 sq mi | Clarendon School District 3 / 6,573 |
| 70. | 117.77 sq mi | Lexington School District 4 / 18,396 |
| 71. | 110.27 sq mi | Dillon School District 1 / 5,462 |
| 72. | 109.66 sq mi | Anderson School District 5 / 79,906 |
| 73. | 106.08 sq mi | Spartanburg School District 5 / 42,810 |
| 74. | 101.59 sq mi | Greenwood School District 52 / 7,364 |
| 75. | 92.27 sq mi | Lexington School District 2 / 63,624 |
| 76. | 90.77 sq mi | Barnwell School District 19 / 5,004 |
| 77. | 89.86 sq mi | Barnwell School District 29 / 5,368 |
| 78. | 86.98 sq mi | Greenwood School District 51 / 7,101 |
| 79. | 86.52 sq mi | Marion School District 2 / 11,648 |
| 80. | 82.16 sq mi | Florence School District 5 / 5,213 |
| 81. | 81.56 sq mi | Fort Jackson Schools / 14,761 |
| 81. | 81.56 sq mi | Richland County School District 2 within Fort Jackson / 14,761 |
| 83. | 81.55 sq mi | Florence School District 4 / 6,032 |
| 84. | 80.06 sq mi | Spartanburg School District 3 / 16,307 |
| 85. | 53.83 sq mi | York School District 4 / 54,198 |
| 86. | 49.99 sq mi | Sumter School District 17 / 50,204 |
| 87. | 49.16 sq mi | Spartanburg School District 7 / 53,770 |
| 88. | 8.77 sq mi | Beaufort County School District within Beaufort Marine Corps Air Station / 949 |
| 88. | 8.77 sq mi | Beaufort Marine Corps Air Station School District / 949 |
Please note that we only rank locations with 'Land Area' data. The rank above might not be a complete list. Locations without 'Land Area' data are not listed.
